Luo Weiren, National Clinical Research Center for Infectious Diseases: cancer is an ecological disease, not a genetic disease.
Dr. Luo Weiren of Shenzhen third people's Hospital / National Clinical Research Center of Infectious Diseases published a review paper in the international well-known journal Theranostics (IF=11.600). He pointed out that tumor (including nasopharyngeal carcinoma) is essentially an ecological disease with multi-dimensional spatio-temporal ecological evolution, which opens a new field of vision for tumor prevention and treatment. Tumor microenvironment is the main determinant of tumor heterogeneity and evolution. the occurrence and development of tumor can be regarded as a pathological ecological process of the interaction, decline or co-evolution between tumor cells and microenvironment. It can be regarded as an ecological factor affecting the ecological adaptability of tumor population. Tumor evolution and ecology are the only light that illuminates each other, "for example, in tumor ecosystems such as nasopharyngeal carcinoma." various tumor cell populations are carried out in complex microenvironments. The optimal decision is made through the dynamics of ecological evolution, and the evolution of tumor also makes the inhibitory immune signal recruit in the tumor stroma.
Source: [People's Daily Health client]
On March 5th, Dr. Luo Weiren of Shenzhen third people's Hospital / National Clinical Research Center of Infectious Diseases published a review paper in the international well-known journal Theranostics (IF=11.600). It was pointed out that tumor (including nasopharyngeal carcinoma) is essentially an ecological disease of multi-dimensional spatio-temporal ecological evolution, rather than a genetic disease, which opens a new field of vision for tumor prevention and treatment.
The paper points out that tumor microenvironment is the main determinant of tumor heterogeneity and evolution, and the occurrence and development of tumor can be regarded as a "yin-yang" pathological ecological process of the interaction, growth and decline or co-evolution between tumor cells and microenvironment. 2022 the latest "Hallmarks of Cancer" can be regarded as an ecological factor affecting the ecological fitness of tumor populations. The article holds that "tumor evolution and ecology are the only light that illuminates each other."
For example, in tumor ecosystems such as nasopharyngeal carcinoma, various tumor cell groups interact "intelligently" in a complex microenvironment, respond quickly to the stimuli of external factors, and make optimal decisions through ecological evolutionary dynamics. In addition, tumor evolution also causes the recruitment of inhibitory immune signals in the tumor stroma, which leads to tumor immune escape. Tumor cells and microenvironment jointly construct a "community with a shared future for tumor ecology". The mutually beneficial symbiotic relationship between them can be explained by the agro-ecological culture model "mulberry pond".
The paper emphasizes that the occurrence and development of human cancer, such as from normal to pathological changes, from early to late, from local to spread, can be regarded as an ecological disease, a multi-dimensional and cross-organizational process of spatio-temporal ecological evolution. In this eco-pathological system, parenchyma cells interact with their specific microenvironment and abiotic factors, and even co-evolve and adapt. As a result, the research team constructed the human tumor ecological tree, which provides a comprehensive framework understanding and research direction for this field.
Editor: Chen Longfei
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